Project 4: Connectivity of the Social Decision-Making System. R. Adolphs, PI

Project 4 tackles a fundamental set of open questions left by all the other Projects: how do the components of the social decision-making network interact at the systems level to compute value and guide choice? This last Project will take our investigations of the social decision-making system to the network level and investigate the connectivity among its components using techniques such as pharmacological inactivation, human amygdala lesion studies, spike-field coherence, direct electrical stimulation, and BOLD coherence. It leverages developments in tractography and coherence analyses, as well as the availability of pharmacological inactivation in monkeys and two rare human subjects with bilateral amygdala lesions. It also paves the way for major future efforts, beyond the scope of the present application, eventually to understand the complete functional architecture for social decision-making.